ABSTRACT
Com o objetivo de determinar as causas para o súbito aumento no número de surtos de intoxicação por organofosforados foram analisados nove surtos da intoxicação diagnosticados em bovinos no Laboratório Regional de Diagnóstico da Faculdade de Veterinária da Universidade Federal de Pelotas (LRD/UFPel) entre novembro de 2013 e fevereiro de 2014. Em todos os surtos os animais foram tratados com concentrações entre duas e 151 vezes maiores que a concentração recomendada de diazinon para banho carrapaticida utilizado nas diferentes propriedades. Contribuíram, ainda, para o grande número de casos de intoxicação a via de adminstração pour on não recomendada para os produtos utilizados e o intenso calor registrado na época de ocorrência dos surtos.
In order to determine the cause of the sudden increase in the number of outbreaks of organophosphate poisoning, nine outbreaks diagnosed in cattle were analyzed at the Laboratório Regional de Diagnóstico, Faculdade de Veterinária, Universidade Federal de Pelotas (LRD/UFPel) between November 2013 and February 2014. In all outbreaks the animals were treated with concentration from two to 151 times higher than the concentration recommended of diazinon for tick treatment. The incorrect route of application, and the intense heat recorded at the time of the outbreaks also contributed to the large number of poisoning.
Subject(s)
Animals , Cattle , Administration, Cutaneous , Atropine/administration & dosage , Diazinon/administration & dosage , Diazinon/adverse effects , Organophosphate Poisoning/veterinary , Diazinon/toxicity , Dosage/adverse effectsABSTRACT
A preliminary survey of domestic rodent and the efficacy of bendiocarb, diazi-non and pirimiphos-methyl insecticides to their fleas were carried out in Dakahlia Governorates [Aga, Meet-Ghamr, El-Senbellawen, Temi El-Amded, Eeni-Abed, Dekernes, Nabarow, Talkha, Menia El-Nasr and El-Kordy]. Rodent index [number of rodent /trap] and percentage frequency of drodent species were recorded from October 2010 to May 2011. The main rodent species found were the Norway rat, Rattus norvegicus, the grey-bellied rat, R, rattus alex-andrinus, the white-bellied rat, R. r. frugivorus and the house mouse, Mus muscu-lus. The rodent index at Beni-Abed, Nabarow, Meet-Ghamr, Dekernes and El-Kordy centers showed 0.46, 0.39, 0.34, 0.33 and 0.33, respectively, while Menia El-Nasr center showed the lowest [0.08]. Aga, Talkha, El-Senbellawen, and Temi El-Amded centers showed moderate [0.25, 0.21, 0.2 and 0.16, respectively]. The com-monest flea species was the oriental rat flea, Xenopsylla cheopis, the mouse flea, Leptopsylla segnis, the dog flea, Ctenocephalides canis and the sticktight flea Echidnophaga gallinacea. The highest number of fleas was on R. norvegicus [Flea index=10.9] while lowest number was on Mus musculus [Flea index=0.1]. X. cheopis was the highest frequency distributed for all domestic rodent species [60.9%], while, C. canis was the lowest [1.6%]. The results showed tfiat bendiocarb was effective [Lc5o=0.389%] than diazinon [Lc5o=1.039%] and pirimiphos-methyl [Lc5o -2.056%]
Subject(s)
Humans , Male , Female , Phenylcarbamates , Diazinon , Diazinon/adverse effects , Organophosphorus Compounds , Insecticides/adverse effects , InsecticidesABSTRACT
Diazinon [DZN] is an organophosphate that inhibits of acetylcolinesterase activity by phosphorylating is active site, in which could be resulted in damages of germinal cells and reproductive functions. Since this compound is extensively using in the agriculture, especially in the northern regions of Iran in order to control of pests, the present study was performed to investigate the influence of DZN on spermatogenesis in mice. Male mice were divided into three experimental, sham and control groups. The animals in the experimental group were injected with the consecutive doses of DZN [30mg/kg i.p, five consecutive days per week for one month]. The sham mice were received only water injection and no injection was performed on animals in the control group. Animals were scarified 35 days after the latest injection of DZN. Then, the mice testis sections were prepared and morphologic aspects of testis and spermatogenesis processes assessed. The DZN showed a significant decrease in number of germ cells, spermatocytes, spermatids, Leydig cells, blood vessels. In addition, the diameter of seminiferous in the testis of the mice decreased. The current finding showed that Diazinon is an environmental factor that can cause toxic effects on the morphologic parameters of germ cells. These results suggested that the DZN might be a factor that results in infertility in mice